Bacteriophages are viruses that infect bacteria. We study Interactions between bacteria, bacteriophages, and the immune system. We are particularly interested in phage–bacteria and phage-immune cell interactions that modulate disease.
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New paper: Dr. Laura Jennings published her paper "Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies" in Cell Reports, Vol 34, Issue 8, 23 February 2021. Click here to read.
Student success spring 2021: Undergraduate Devin Hunt achieved a perfect score on the MCAT! See this link for the full story. This spring, Devin will be joining the National Institute of Allergy and Infectious Disease as an IRTA Post-Baccalaureate Fellow with the Centralized Sequencing Initiative. Congrats Devin!
New grant, March 2021: Congratulations to Margie Kinnersley on her Montana INBRE proposal exploring phages as drivers of genetic variation in Borrelia burgdorferi (Lyme disease).
New grant, June 2020: We are grateful to the NIH NIDDK for supporting our E. coli phage work in collaboration with the Round lab at the University of Utah. The goal of this project is to determine how lysogenic phages that infect adherent invasive E. coli affect inflammatory diseases in the gut. See our recent commentary here.
New grant, March 2020: We are grateful to the NIH NIAID for supporting our Borrelia phage work. The goal of this project is to determine the role of ΦBB-1 phages in spirochete transmission and Lyme disease pathogenesis.
New paper: Secor and Dandekar, More than Simple Parasites: the Sociobiology of Bacteriophages and Their Bacterial Hosts. mBio March 10, 2020. https://mbio.asm.org/content/11/2/e00041-20
New paper: Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic infections. Secor et al., Front. Immunol., 21 February 2020 | https://doi.org/10.3389/fimmu.2020.00244
In the media: Undergraduate Devin Hunt featured in a University of Montana Commercial:
New paper: The Immune Response to Chronic P. aeruginosa Wound Infection in Immunocompetent Mice,
Sweere et al., Advances in Wound Care, Dec 2019, https://doi.org/10.1089/wound.2019.1039
In the media: The lab was featured in Vision Magazine: From Bench to bedside. https://medium.com/vision-2019/from-bench-to-bedside-1132299c11e0
Our work was featured on ASMs This Week in Microbiology! http://www.microbe.tv/twim/twim-198/
April 2019: Undergraduate Autumn Robinson was nominated as student employee of the year 2019. Congrats Autumn!!
April 2019: Another paper out in collaboration with Paul Bollyky and team in Science Translational Medicine. "Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis"
April 2019: New paper in collaboration with Paul Bollyky and team in Science. "Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection"
Oct 1st, 2018: Our aggregate work was published in PNAS! Lab members Lia Michaels and Laura Jennings are authors. Congrats to all! UM press release: http://bit.ly/2zKjZfr
June 8, 2018: Our R01 was FUNDED!! This grant from the NIH NIAID will allow us to develop an anti-phage vaccine to treat and prevent bacterial infections. In collaboration with the Bollyky lab at Stanford and Chanden Sen at Indiana. Check out this related piece in the local paper here.
June 2018: Lia and Caleb presented their work at the 2018 Wind River Conference on Prokaryotic Biology. Lia was selected for a Lightning Talk and Caleb won a Travel Award. Congrats to them both!
April 2018: Pat presented at the OBEE Brewery CHALK Talk Series at Imagine Nation Brewery in Missoula, MT. Check out the line-up here: cooper-lab.org/chalk.html
April 27, 2018: Jake and Autumn presented their work at the 2018 UM Conference on Undergraduate Research. Autumn received a Conference Award for her poster presentation "A bacteriophage integrase regulates virulence factor production in Pseudomonas aeruginosa." Congratulations Autumn!
April 2018: Thank you to the University of Montana's Genome Core Facility and Illumina for supporting our
P. aeruginosa bacteriophage work!
Dec. 2017: Our proposal to study filamentous Pf bacteriophage as a therapeutic target was funded by the Falk Charitable trust! This project is a collaboration between the Secor Lab at the University of Montana, the Bollyky Lab at Stanford, The Ohio State, and Baylor University. See UMs press release for more info.