Publications

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For our most up-to-date publication list, click here.

Schmidt AK, Schwartzkopf CM, Pourtois JD, Burgener E, Faith DR, Joyce A, Lamma T, Kumar G, Bollyky PL, Secor PR. 2024. Targeted deletion of Pf prophages from diverse Pseudomonas aeruginosa isolates impacts quorum sensing and virulence traits. Journal of Bacteriology, in press

Copeland CJ, Roddy JW, Schmidt AK, Secor PR, Wheeler TJ. 2024. VIBES: A Workflow for Annotating and Visualizing Viral Sequences Integrated into Bacterial Genomes. NAR Genomics and Bioinformatics, Vol 6, Issue 2, June 2024

Faith DR, Kinnersley M, Brooks DM, Drecktrah D, Hall LS, Luo E, Santiago-Frangos A, Wachter J, Samuels DS, Secor PR. 2024. Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1. PLoS Pathogens, 2024;20(4):e1012122. doi: 10.1371/journal.ppat.1012122

Román-Cruz VC, Miller SM, Schoener RA, Lukasiewicz C, Schmidt AK, DeBuysscher BL, Burkhart D, Secor PR, Evans JT. 2024. Adjuvanted Vaccine Induces Functional Antibodies against Pseudomonas aeruginosa Filamentous Bacteriophages. Vaccines 12:115

Schwartzkopf, C.M., Taylor, V., Groleau, M-C., Faith, D. R., Schmidt, A. K., Lamma, T., Brooks, D. M., Déziel, E., Maxwell, K., and Secor, P. R.#. Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa. Molecular Microbiology. 2024; doi:10.1111/mmi.15202

C. D. de Mattos, D. R. Faith, A. A. Nemudryi, D. C. Bublitz, L. Hammond, M. A. Kinnersley, C. M. Schwartzkopf, A. J. Robinson, A. Joyce, L. A. Michaels, R. S. Brzozowski, A. Coluccio, D. D. Xing, J. Uchiyama, L. K. Jennings, P. Eswara, B. Wiedenheft, P. R. Secor. Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection. PNAS, 2023, https://doi.org/10.1073/pnas.2216430120.

Schwartzkopf CM, Robinson AJ, Ellenbecker M, Faith DR, Schmidt AK, Brooks DM, Lewerke L, Voronina E, Dandekar AA, Secor PR. Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes. PLoS Pathog. 2023;19(2):e1010925. Epub 20230217. doi: 10.1371/journal.ppat.1010925.

Wachter, J., Cheff, B., Hillman, C., Carracoi, V., Dorward, D.W., Martens, C., Barbian, K., Nardone, G., Olano, R.L., Kinnersley, M, Secor, P.R., and Rosa, P.A. Coupled induction of prophage and virulence factors during tick transmission of the Lyme disease spirochete. Nature Communications, 2023 https://doi.org/10.1038/s41467-023-35897-3.

M. T. van Rossem, S. Wilks, P. R. Secor, M. Kaczmarek, G. D’Alessandro. Homogenization modelling of antibiotic diffusion and adsorption in viral liquid crystals. Royal Society Open Sci, Vol 10, Issue 1, Jan. 2023, doi.org/10.1098/rsos.221120

M. S. Bach, C. R. de Vries, A. Khosravi, J. M. Sweere, M. C. Popescu, Q. Chen, S. Demirdjian, A. Hargil, J. D.Van Belleghem, G. Kaber, M. Hajfathalian, E. B. Burgener, D. Liu, Q. Tran, T. Dharmaraj, M. Birukova, V. Sunkari, S. Balaji, N. Ghosh, S. S. Steiner, M. S. El Masry, S. G. Keswani, N. Banaei, L. Nedelec, C. K. Sen, V. Chandra, P. R. Secor, G. A. Suh, P. L. Bollyky. Filamentous bacteriophage delays healing of Pseudomonas-infected wounds. Cell Reports Medicine, Vol 3, Issue 6, June 2022, https://doi.org/10.1016/j.xcrm.2022.100656

fcimb.2022.869736

Faith, D., Kinnersley, M., Schwartzkopf, C.M., de Mattos, C.D., Schmidt, A.K., and Secor, P.R. (2022). Complete Genome Sequence of the N4-like Pseudomonas aeruginosa Bacteriophage vB_PaeP_CMS1. Microbiol Resour Announc, e0023922. 10.1128/mra.00239-22.

Amelia K Schmidt , Alexa D Fitzpatrick , Caleb M Schwartzkopf , Dominick R Faith , Laura K Jennings , Alison Coluccio , Devin J Hunt , Lia A Michaels , Aviv Hargil , Qingquan Chen , Paul L Bollyky, David William Dorward, Jenny Wachter, Patricia A Rosa, Karen L Maxwell , Patrick R Secor (2022). A Filamentous Bacteriophage Protein Inhibits Type IV Pili to Prevent Superinfection of Pseudomonas aeruginosa, mBio, 13 (1), e02441-21

Laura K. Jennings, Julia E. Dreifus, Courtney Reichhardt, Kelly M. Storek, Patrick R. Secor, Daniel J. Wozniak, Katherine B. Hisert, and Matthew R. Parsek. Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies. Cell Reports, Volume 34, Issue 8, 23 February 2021

Elizabeth B. Burgener, Patrick R. Secor, Michael C. Tracy, Johanna M. Sweere, Elisabeth M. Bik, Carlos E. Milla, and Paul L. Bollyky. Methods for Extraction and Detection of Pf Bacteriophage DNA from the Sputum of Patients with Cystic Fibrosis, Phage: Therapy, Applications, and Research, June 2020,

doi.org/10.1089/phage.2020.0003

Secor and Dandekar, More than Simple Parasites: the Sociobiology of Bacteriophages and Their Bacterial Hosts. mBio, March 10, 2020, https://mbio.asm.org/content/11/2/e00041-20

Secor et al., Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic infections. Front. Immunol., 21 February 2020 | https://doi.org/10.3389/fimmu.2020.00244

Sweere et al., The Immune Response to Chronic Pseudomonas aeruginosa Wound Infection in Immunocompetent Mice. Advances in Wound Care Dec 2019, DOI: 10.1089/wound.2019.1039

Burgener et al., Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis. Science Translational Medicine 17 Apr 2019:Vol. 11, Issue 488, eaau9748

JM Sweere, JD Van Belleghem, H Ishak, MS Bach, M Popescu, V Sunkari, et. al., Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. 2019. Science 363 (6434), eaat9691

PL Bollyky, PR Secor. The Innate Sense of Bacteriophages. 2019. Cell Host & Microbe 25 (2), 177-179

Secor P.R., Michaels, L.A., Ratjen, A., Jennings, L.K., Singh, P.K. Entropically-driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa. Proc Natl Acad Sci USA, Oct 2018, 201806005; DOI:10.1073/pnas.1806005115

Jorth, P.A., McLean, K., Ratjen, A., Secor, P.R., Bautista, G.E., Ravishankar, S., Rezayat, A., Garudathri, J., Harrison, J.J., Harwood, R.A., Penewit, K., Waalkes, A., Singh, P.K., SalipaNTE, S.J. (2017) Evolved aztreonam resistance is multifactorial and can produce hypervirulence in Pseudomonas aeruginosa. mBio, Oct. 2017, vol. 8 no. 5 e00517-17.

Nazik, H., Joubert, L.M., Secor, P.R., Sweere, J.M., Bollyky, P.L., Sass, G., Cegelski, L., Stevens, D.A. (2017) Pseudomonas Phage Inhibition of Candida albicans. Microbiology, 2017 Nov;163(11):1568-1577. doi: 10.1099/mic.0.000539.

PR Secor, G Sass, H Nazik, DA Stevens. 2017. Effect of acute predation with bacteriophage on intermicrobial aggression by Pseudomonas aeruginosa. PloS One, 12 (6), e0179659

PR Secor et al. 2017. Filamentous bacteriophage produced by Pseudomonas aeruginosa alters the inflammatory response and promotes noninvasive infection in vivo. Infection and immunity, 85 (1), e00648-16

AM Ratjen, PR Secor, PK Singh. 2016. CF airway polymers drive bacterial aggregation and activate bacterial stress responses that promote antibiotic tolerance. Pediatric Pulmonology, 51, 336-336.

JC Penner, JAG Ferreira, PR Secor, JM Sweere, MK Birukova, LM Joubert, et al. 2016. Pf4 bacteriophage produced by Pseudomonas aeruginosa inhibits Aspergillus fumigatus metabolism via iron sequestration. Microbiology, 162 (9), 1583-1594.

PR Secor, LK Jennings, LA Michaels, JM Sweere, PK Singh, WC Parks, PL Bollyky. 2016. Biofilm assembly becomes crystal clear–filamentous bacteriophage organize the Pseudomonas aeruginosa biofilm matrix into a liquid crystal. Microbial Cell, 3 (1), 49.

PR Secor, JM Sweere, LA Michaels, AV Malkovskiy, D Lazzareschi, et al. 2015. Filamentous bacteriophage promote biofilm assembly and function. Cell Host & Microbe 18 (5), 549-559.

PR Secor, LA Michaels, PK Singh. 2015. Host And Microbial Polymers Passively Aggregate Cf Pathogens Producing Resistance To Killing And Promoting Interspecies Interactions. Pediatric Pulmonology, 50, 308.

LK Jennings, KM Storek, HE Ledvina, C Coulon, LS Marmont, I Sadovskaya, PR Secor, et al. 2015. Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix.

Proceedings of the National Academy of Sciences, 112 (36), 11353-11358.

PR Secor, LK Jennings, GA James, KR Kirker, E deLancey Pulcini, et al. 2012. Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression. PloS One, 7 (7), e40973182012.

PR Secor, GA James, P Fleckman, JE Olerud, K McInnerney, PS Stewart. 2011. Staphylococcus aureus Biofilm and Planktonic cultures differentially impact gene expression, MAPK phosphorylation, and cytokine production in human keratinocytes. BMC Microbiology 11 (1), 143.

KR Kirker, PR Secor, GA James, P Fleckman, JE Olerud, PS Stewart. 2009. Loss of viability and induction of apoptosis in human keratinocytes exposed to Staphylococcus aureus biofilms in vitro. Wound repair and regeneration, 17 (5), 690-699.